Nootropics are a smart drug that enhances cognition and memory and facilitates learning. Disorders like Alzheimer's disease, Fronto-temporal Dementia, Huntington's disease, Lewy Body Dementia, Mild Cognitive Impairment, Vascular Dementia etc. these are the main cause of memory disabilities. Traditional system of herbal medicinal plants has been used to improve memory and cognitive function and to treat neurodegenerative diseases. The objective of present study was to evaluate the nootropic effect of isoflavonoid rich fraction of Solanum torvum seeds in mice. Nootropic effects of combination of sildenafil and IRF of STME was evaluated in different learning and memory paradigm viz. Elevated plus maze and Morris water maze. Isolation and Identification of IRF of STME from Solanum torvum seeds by different analytical techniques. Moreover, monoamines mediated behaviour studied by NaNO2 induced respiratory arrest and influence on central cholinergic activity via estimating the whole brain acetylcholinesterase enzyme and also histopathological examination of brain hippocampus region of all groups in mice. Treatment with Scopolamine significantly decreased memory while STME, IRF of Solanum torvum seeds and their combinations with sildenafil significantly elevated acetylcholine levels in brain through decrease in cholinesterase activity and ultimately improved memory of mice than methanolic extract of Solanum torvum seeds and monotherapies. Overall, the study outcomes suggest the significant memory enhancement with the sildenafil and IRF of STME combination treatment.
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